By Douglas P. Clark MD, William C. Faquin MD, PhD (auth.)
Thyroid Cytopathology, the inaugural quantity of the necessities in Cytopathology sequence, presents an summary to the exam and analysis of thyroid cytology specimens. each one concise laptop reference within the necessities in Cytopathology sequence is designed as an easy-to-use and authoritative synopsis of site-specific subject matters in cytopathology.
Thyroid Cytopathology makes use of an easy algorithmic method of the prognosis of thyroid nice needle aspirations (FNA). This hassle-free, reference starts with an creation to medical facets, a advisor to acting and processing thyroid FNAs, and an summary to the algorithmic method of thyroid FNA cytopathology. equipped in eleven easy-to-read chapters, this quantity discusses the history, diagnostic techniques and standards, differential diagnoses, and scientific administration of inflammatory, colloid, follicular, Hurthle mobile and cystic lesions, in addition to, papillary, medullary and undifferentiated carcinomas.
With greater than one hundred fifteen full-color photographs, 12 tables and a chain of algorithms, Thyroid Cytopathology is the best fast reference consultant protecting the necessities of thyroid FNA. it's a must-have for each pathologist, cytopathologist, cytotechnologist, fellow and trainee.
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Extra info for Thyroid Cytopathology
Nuclei of the intermediate-size cells are slightly irregular with condensed chromatin and indistinct nucleoli. Some cells have more abundant pale cytoplasm, 44 4. Inﬂammatory Lesions and Lymphoma giving a monocytoid appearance. 14). Because it may be difﬁcult if not impossible to distinguish MALT lymphoma from a benign condition, immunophenotypic analysis such as ﬂow cytometry to demonstrate light chain restriction is essential. The immunoproﬁle of MALT lymphomas is generally CD20+ and CD45+, but CD5-, CD10-, and CD23-.
Tingible body macrophages are not present. ) • • • • • Scattered immunoblasts and plasma cells Lymphohistiocytic aggregates Monotypic light chain restriction CD20+, CD45+, CD5-, CD10-, CD23Cyclin D1- Differential Diagnosis and Pitfalls A challenging diagnostic problem in thyroid cytology is the distinction of Hashimoto’s thyroiditis from MALT lymphoma because of the heterogeneous population of lymphocytes in each. Cytologic differences between these two can be very subtle, but features favoring Hashimoto’s thyroiditis include a combination of lymphocytes in all stages of maturation with a predominant population of small mature lymphocytes and admixed plasma cells, and lymphohistiocytic aggregates with 46 4.
Burguera B, Gharib H. Thyroid incidentalomas. Prevalence, diagnosis signiﬁcance, and management. Endocrinol Metab Clin N Am 2000;29(1):187–203. NCCLS. Fine needle aspiration biopsy (FNAB) techniques; approved guideline. NCCLS document GP20-A. NCCLS, 940 West Valley Road, Suite 1400, Wayne, PA, 1986. Tulecke MA, Wang HH. ThinPrep for cytologic evaluation of follicular thyroid lesions: correlation with histologic ﬁndings. Diagn Cytopathol 2004;30(1):7–13. 1). This approach uses a combination of lowmagniﬁcation assessment of cellular components, evaluation of cytoarchitectural patterns, and high-magniﬁcation scrutiny of nuclear features.