Herpes by Juliet V. Spencer, I. Edward Alcamo, David Heymann

By Juliet V. Spencer, I. Edward Alcamo, David Heymann

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Whereas many viruses can only replicate in actively dividing cells—those that have replication enzymes readily available—HSV is cell-cycle independent. q 3/10/08 9:49 AM Page 33 Nature’s Design: Virus Structure cells that are not actively dividing, such as neurons (nerve cells, like those in the brain). This feature plays a key role in the ability of the virus to establish latency in neurons. Virus replication is described in greater detail in Chapter 4, and latency is discussed in Chapter 5. During virus infection, the last genes to be transcribed are those that encode structural proteins that are involved in assembly of new virus particles.

4). 4 Apoptosis, or programmed cell death, is an ordered series of events that leads to the complete removal of the selected cell. In response to death signals, a cellsignaling cascade is activated, resulting in condensation of the cell and fragmentation of the cellular DNA. Ultimately, the cell fragments are engulfed by phagocytic white blood cells and all traces of the cell are gone. in the host are right, and the latent virus can shift to productive infection in which the infectious virus may be transmitted to other susceptible individuals.

7). q 3/10/08 9:50 AM Page 54 5 Lying in Wait: Virus Latency The following letter appeared in a local newspaper: Dear Heloise, Help, I can’t get rid of roaches! I’ve tried so many chemicals the family and pets should be dead. I can’t afford a monthly fee to have someone come in all the time. I’ve emptied every cupboard and have sprayed, powdered and sealed. Nothing works. They leave during the day but at night are back and it seems they bring more friends. My walls, baseboards and cupboards are being ruined by the constant spraying.

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