Handbook of Toxicologic Pathology, 2nd edition by Wanda M. Haschek, Colin G. Rousseaux and Matthew A. Wallig

By Wanda M. Haschek, Colin G. Rousseaux and Matthew A. Wallig (Eds.)

  • ''The 2 volumes are very good partners that supplement one another as a ''1,2'' punch! This booklet will be at the bookshelf of scientific toxicologists, environmental pros and laboratory investigators...''
    ''...gives a superb evaluation of the various tactics linked to toxicologic pathology as utilized in hazard overview. It stands by myself as a vintage textbook in toxicology, or will be a good complement to different such books. ...Its clarity will enable popularity to all scientists starting from undergraduate to skilled industry/regulatory professional.''
    -Paul Baldrick for THE BRITISH TOXICOLOGY SOCIETY publication (Spring 2002)
    ''...very readable, well-referenced, and current... a very good booklet for study training.''

    ''[W]ell illustrated with quality diagrams, color and black and white photographs…. [A]n very good, eminently readable ebook to have as a learn or reference ebook, masking the fundamental fundamentals and offering a great assessment for any toxicological pathologist, toxicologist or study scientist with an curiosity within the pathological alterations obvious in toxicological studies.''--British Toxicology Society Newsletter

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Additional info for Handbook of Toxicologic Pathology, 2nd edition

Example text

Both potentiate the toxicities of acetaminophen and bromobenzene. The area of synergism and potentiation of toxicities deserves a great deal of attention if our knowledge of toxicology is to be more than academic, as exposure to a polluted environment seldom consists of exposure to a single chemical. 32 2. Biochemical Basis of Toxicity platelet. Furthermore, a low dose of aspirin undergoes hepatic metabolism and systemic dilution. Platelet cyclooxygenase can be inactivated in the portal system immediately following absorption and prior to metabolism or dilution, but insufficient aspirin reaches the circulatory system to inhibit endothelial cyclooxygenase.

This too could be determined by hair analysis. Storage of xenobiotics, such as selenium in horse hooves, can adversely affect hoof function and therefore cannot be termed excretion. Similarly, "excretion" of PCBs into milk is of questionable service, as it serves to intoxicate the neonate even though it clears the 2. Biochemical Basis of Toxicity mother. Awareness of excretion into milk has led to growing concern for the passage of social drugs and environmental pollutants from mother to child.

FREERADICALS AND LIPID PEROXIDATION When a xenobiotic is bioactivated to an intermediate that breaks down to a free radical, an available source of hydrogen atoms to quench the radical is the unsaturated lipid of the cell membranes. The lipid radical thus formed by removal of the hydrogen atom interacts readily with oxygen to form a peroxy radical. Quenching of the peroxy radical by a hydrogen atom abstracted from a second unsaturated lipid leaves a lipid peroxide and produces a new lipid radical, thus propagating lipid peroxidation.

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