By World Health Organization
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Additional info for Guidelines on Sterilization and Disinfection Methods Effective Against Human Immunodeficiency Virus
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The value of θmax is, therefore, a measure of genetic distance between two loci. The second parameter, zmax, is a measure of how good that estimate of θmax actually is. 5, linkage is strongly suggested. If zmax is larger than 3, the likelihood that the loci are linked is a thousand times (103) greater than the likelihood that the linkage data are purely the result of chance. Thus LOD scores with zmax of 3 or greater are taken as nearly deﬁnitive proof that two loci are linked. LOD score analysis will demonstrate which polymorphic loci of known location are linked to the disease by ﬁnding the smallest value of θmax with the largest zmax, preferably 3 or greater.