Essentials of pathophysiology for pharmacy: An Integrated by Martin M. Zdanowicz

By Martin M. Zdanowicz

Providing all of the info your scholars want in an obtainable structure, necessities of Pathophysiology for Pharmacy will supply scholars a realistic realizing of the pathophysiologic foundation of chosen illnesses whereas offering a purpose for next drug remedy.

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Define polycythemia. 29 TX366_book Page 30 Friday, July 12, 2002 1:00 PM TX366_book Page 31 Friday, July 12, 2002 1:00 PM Chapter four: Alterations in hematologic function and oxygen transport 31 Introduction Blood is composed of two main components: a liquid portion called plasma and a cellular portion containing red blood cells (erythrocytes), white blood cells (leukocytes) and platelets (thrombocytes). Blood serves a number of important functions in the human body such as transport of oxygen, nutrients and ions while acting as a buffer between cells and the environment.

This process of fibrinolysis or clot dissolution is accomplished by the enzyme plasmin that digests the fibrin strands of the clot as well as several clotting factors. Plasmin travels in circulation as the inactive pro-enzyme plasminogen. Factors produced by the liver and vascular endothelium called plasminogen activators — tissuetype plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA) — convert the pro-enzyme plasminogen to the active fibrinolytic enzyme plasmin. The activity of plasmin is in turn regulated by the inhibitory enzyme α2-plasmin inhibitor, which rapidly inactivates it.

For example, a hepatoma is a benign tumor of the liver, whereas a hepatocarcinoma is a malignant tumor. 2 Characteristics of Neoplasia Benign Slow growth rate Encapsulated Well-differentiated cells Resemble tissue of origin Do not metastasize Malignant Rapid growth rate Non-encapsulated Undifferentiated (anaplasia) Loss of contact inhibition Metastasize readily Express foreign antigens Abnormal gene expression TX366_book Page 14 Friday, July 12, 2002 1:00 PM 14 Essentials of Pathophysiology for Pharmacy Malignant neoplasm — Tumors that have the ability to metastasize or break loose and spread to other areas of the body.

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