Epidemiology of Leukaemia and Lymphoma. Report of the by M. F. Greaves

By M. F. Greaves

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Additional info for Epidemiology of Leukaemia and Lymphoma. Report of the Leukaemia Research Fund International Workshop, Oxford, UK, September 1984

Sample text

These human T-cell leukaemia/lymphoma viruses (HTLV) are RNA viruses which are exogoneous and horizontally transmitted with mature T-cell trophism and capacity for transforming or lysing their target lymphocyte in vitro. As a corollary to these in vitro effects, these viruses appear to cause lymphoproliferative and/or immunosuppressive diseases in man. The prototype HTLV-I was discovered in patients with a particular form of mature T-cell malignancy called adult T-cell leukaemia/lymphoma (ATL).

An additional preliminary analysis of annual childhood leukaemia (CL) incidence has recently been performed on all patients diagnosed from 1980 till 1983. Annual rates per 5-yr age group of patients with CL, ALL, ANLL and CML have been standardised to the 1979 population. Mortality data pertaining to cause of death in the 1969-1982 period were also acquired through the Central Bureau of Statistics. Rates were computed per two consecutive years. In a search for possible clusters, statistical analyses have been performed on the data of 293 patients living in the Western part of the country.

25-103. Plenum Press, New York. 17. Zeng Y. & de Thé G. (1985) Nasopharyngeal carcinoma: early detection and IgA related pre-NPC conditions. Achievements and prospectives. In Proc. 1st Int. ) (in press). EPIDEMIOLOGY OF HUMAN RETROVIRUSES WILLIAM A. BLATTNER and ROBERT C. A. trum of clinical manifestations ranging from cases that are typical non-Hogkin's lymphoma to cases with features of adult T-cell leukaemia to cases with cutaneous T-cell lymphoma indistinguishable from mycosis fungoides/Sezary syndrome.

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