Epidemiology of Alzheimer’s Disease: From Gene to Prevention by R. Katzman, P. J. Fox (auth.), Richard Mayeux MD, Y.

By R. Katzman, P. J. Fox (auth.), Richard Mayeux MD, Y. Christen Ph.D. (eds.)

This quantity comprises the lawsuits of the 14th Colloque Médecine et Recherche of the Fondation Ipsen pour l. a. Recherche Thérapeutique dedicated to Alzheimer's disorder and devoted to the epidemiological examine of this dementia, a crucial factor as the occurrence and incidence of Alzheimer's affliction upward thrust exponentially with age. Epidemiological findings not just ascertain dementia as an enormous problem for the arriving years but additionally give a contribution defining hazard elements, predicting and will be fighting this disease.

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Additional info for Epidemiology of Alzheimer’s Disease: From Gene to Prevention

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1997) and it is frequent enough to deserve our attention. Primary and secondary prevention would involve identifying healthy men and women who are at higher than average risk of developing Alzheimer's disease. For example, individuals homozygous or heterozygous for the APOE-E4 allele or those with a family history of Alzheimer's disease in a parent or sibling or another risk factor might be considered at "high risk:' It would be reasonable to start with safe compounds with low adverse effect profiles, such as antiinflammatory agents (Stewart et al.

R. Mayeux / Y. ) Epidemiology of Alzheimer's Disease: From Gene to Prevention © Springer-Verlag Berlin Heidelberg New York 1999 42 s. Radebaugh et al. health problem estimated from the prevalence data of East Boston, and 3) the emerging data indicating the differential distribution of Alzheimer's disease by ethnicity. Although epidemiological data have contributed significantly to the understanding of the disease, there are certain limitations to the generalizability of the data to other heterogeneous populations.

Mayeux late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. JAMA 278: 1237 -1241 Piccini C, Bracco L, Falcini M, Pracucci G, Amaducci L (1995) Natural history of Alzheimer's disease: prognostic value of plateau. J Neurol Sci 131: 177 -182 Poduslo SE, Neal M, Schwankhaus J (1995) A closely linked gene to apolipoprotein E may serve as an additional risk factor for Alzheimer's disease. Neurosci Lett 201 :81-83 Rasmusson DX, Brandt J, Martin DB, Folstein MF (1995) Head injury as a risk factor in Alzheimer's disease.

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