Electrical Diseases of the Heart: Genetics, Mechanisms, by A. A. M. Wilde, P. A. Friedman, M. J. Ackerman, W.-K. Shen,

By A. A. M. Wilde, P. A. Friedman, M. J. Ackerman, W.-K. Shen, Ihor Gussak, Charles Antzelevitch

This publication presents a special modern and succinct distillation of the present prestige of lately delineated electric ailments of the center, emphasizing their universal and various medical gains. the newest advancements within the box of experimental and medical cardiac electrophysiology, genetics, pharmacology and interventional remedies of varied medical arrhythmogenic entities are featured and mentioned by way of contemporary advances in easy and scientific technology. The booklet is split into seven significant components. every one half includes chapters (total of sixty four) facing similar subject matters.

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Additional resources for Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention

Example text

51. Satoh H.

The Ca2+ current then progressively inactivates, whereas K+ currents progressively activate, inducing the cell membrane to repolarize FIGURE 1–4. Schemes of the cardiac action potential and underlying ionic currents (top). This is a dynamic process: activation of the Na+ channels generates the voltage upstroke, which activates the other ionic currents. In return, the action potential modulates the shape of the different currents. Bottom: the different ion channels and transporter species. Arrows represent the different current directions in the action potential voltage range.

Basic Res Cardiol 2002;97:424–433. 36. Wang Z, Yue L, White M, et al. Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle. Circulation 1998;98:2422–2428. 37. Duprat F, Lesage F, Fink M, et al. TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J 1997;16: 5464–5471. 38. Wang J, Schwinger RH, Frank K, et al. Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart.

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