DRUGS:PHOTOCHEMISTRY AND PHOTO by A. ALBINI, E. FASINI

By A. ALBINI, E. FASINI

Provides the elemental parts of the technology, & serves as a superb advent to this rising box of photochemistry. exact experimental stipulations for photostability reviews are given, in addition to a dialogue of the lately applied ICH instructions for drug photostability.

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These are found as an appendix to the present Photochemistry of Drugs:An Overview and Practical Problems 53 chapter, and their application is discussed in several respects by Drew and Helboe (p. 227 and 243, respectively) in this book. 285, 2g6, 3l8-322 In general, it turns out that the qualitative course of the reaction does not change with the lamp, as one may expect, unless the primarily formed photoproducts are thermally or photochemically unstable. The rate of degradation changes greatly, but the results become comparablewhen the actually absorbed light dose, not the overall lamp flux, is taken into account.

Therefore, the solid is rather photostable under anaerobic conditions. 291 Photochemistry of Drugs:An Overview and Practical Problems 51 It has also been noted with several drugs that different polymorphs give different results. 2. Photoreactions in the Presence of Oxygen. The effect of oxygen is also complex. This molecule is an efficient quencher of excited states, viz causes decay to the ground state with no chemical reaction. Thus, it may have a photo-stabilising effect on reactions involving relatively long-lived excited states such as triplets (short-lived singlet states cannot be quenched by oxygen since the concentration of the latter is too low to make a bimolecular reaction such as quenching significant in comparison with monomolecular reactions).

D. Budac and P. Wan,J. Photochem. , 1992,67, 135. 22. K. Reszka and C. F. Chignell, Photochem. , 1983,38,281. 23. F. Bosca, M. A. Miranda, L. Van0 and F. Vargas, J. Photochem. , 1990,54, 131. 24. J. V. J. Gomez-Lechon, M. A. Miranda and I. M. Morrea, Photochem. , 1987,46, 991. 25. J. V. Castell, M. J. Gomez-Lechon, M. A. Miranda and I. M. Morera, J. Photochem. Photobiol. , 1992, 13, 71. 26. Monti, S. Sortino, G. De Guidi and G. Marconi, J. Chem. , 1997, 93,2269. 27. F. Bosca, M. A. Miranda, G. Carganico and D.

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