Drug Targeting Technology: Physical, Chemical and Biological by Richard G. Lyons

By Richard G. Lyons

Discusses actual, chemical, and organic methods to drug concentrating on know-how, concentrating on oral, dispersed process, topical, dermal, transdermal, and inhalation supply, and the improvement of unique formulations matched via cutting edge equipment layout. For researchers.

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Caco-2 cells have been developed as a useful in vitro model to study absorption mechanisms of a variety of drugs. They are also used to measure the relative rates of drug and prodrug permeation across a model colonic membrane (Caco-2 monolayers) [45]. Copyright © 2001 Marcel Dekker, Inc. Figure 1 (A) Colon Microflora Test (CMT) device, an anaerobically working minifermenter consisting of a glass container thermostated by a water bath and hermetically closed by a metal cover plate with several holes for supply pipes.

R. Wilding, The in vivo behaviour of a colonic delivery system: a pilot study in man, Int J Pharm 112:199–206 (1994). 27. T. Tabata, T. Makino, J. Kikuta, S. Hirai, N. Kitamori, Manufacturing method of stable enteric granules of a new antiulcer drug (lansoprazole), Drug Dev Ind Pharm 20(9):1661–1672 (1994). 28. J. McGinity, Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, Marcel Dekker, New York, 1996. 29. K. Lehmann, Acrylic latices from redispersible powders for peroral and transdermal drug formulations, Drug Dev Ind Pharm 12:265–287 (1986).

J. Pharmaceut. 86:35–41 (1992). 18. S. S. Rao, and W. A. P. Pharma Sciences 5:19–29 (1995). 19. A. Rubinstein, B. Tirosh, M. Baluom, T. Nassar, A. David, R. Radai, I. Gliko-Kabir, and M. Friedman, The rationale for peptide drug delivery to the colon and the potential of polymeric carriers as effective tools, J. Controlled Release 46:59–73 (1996). 20. N. Gardner, W. Haresign, R. Spiller, N. Faraj, J. Wiseman, H. Norbury, and L. Illum, Development and validation of a pig model for colon specific drug delivery, J.

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