Drug Stability for Pharmaceutical Scientists by Thorsteinn Loftsson

By Thorsteinn Loftsson

Drug balance for Pharmaceutical Scientists is a transparent and easy-to-follow advisor on drug degradation in pharmaceutical formula. This e-book positive factors precious content material on either aqueous and sturdy drug options, the steadiness of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formula can impression drug balance, the impact of exterior components on response charges and masses extra. packed with examples of real-life formula difficulties and step by step calculations, this e-book is the right source for graduate scholars, in addition to scientists within the pharmaceutical and similar industries.

  • Illustrates very important theoretical innovations with a number of examples, figures, calculations, studying difficulties and questions for self-study and retention of material
  • Provides solutions and factors to check your knowledge
  • Enables you to higher comprehend key strategies reminiscent of price and order of response, response equilibrium, advanced response mechanisms and more
  • Includes an in-depth dialogue of either aqueous and strong drug ideas and comprises the newest foreign regulatory requisites on drug stability

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Drug Stability for Pharmaceutical Scientists

Drug balance for Pharmaceutical Scientists is a transparent and easy-to-follow consultant on drug degradation in pharmaceutical formula. This booklet beneficial properties helpful content material on either aqueous and reliable drug suggestions, the soundness of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formula can effect drug balance, the impact of exterior components on response premiums and masses extra.

Additional info for Drug Stability for Pharmaceutical Scientists

Example text

He, X. Tang, Stability and degradation kinetics of etoposide-loaded parenteral lipid emulsion, J. Pharm. Sci. 96 (2007) 1719À1728. [18] T. J. Olafmiddottir, J. Baldvinmiddottir, Estramustine: hydrolysis, solubilization, and stabilization in aqueous solutions, Int. J. Pharm. 79 (1992) 107À112.

H1]) and the pKa, we can apply Eq. 147 to determine the fraction of the acidic form of the buffer (H2PO42) and Eq. 148 to determine the basic form of the buffer (HPO422). 734 M21 h21 Thus, the general base catalysis is dominating, although some general acid catalysis is also observed. 10 EFFECTS OF IONIC STRENGTH (SALT EFFECTS) If the drug is ionized, the reaction rate is influenced by electrostatic interactions between the drug and other reacting ions, as well as by the ionic strength of the aqueous reaction medium.

177) Under such conditions, protecting the drug product against oxygen will decrease the drug degradation rate. Oxygen can exist in various states. The ground state of oxygen is its triplet state (3O2), but its excited state is singlet oxygen (1O2), which is more reactive than the triplet form: hv Triplet Singlet Singlet oxygen is highly oxidizing (photooxidation), capable of oxidizing unsaturated drug moieties. , peroxides), that are capable of reducing or oxidizing drugs and excipients. , light and metal ions) can enhance oxidative degradation.

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