By Colin A. McCannel MD, FACS (auth.), Aniz Girach, Marc D. de Smet (eds.)
This clinically orientated ebook is the 1st to be dedicated absolutely to the analysis and remedy of vitreo-macular interface ailment, characterised by way of a mixture of vitreo-macular adhesion (VMA) and vitreo-macular traction (VMT) that's implicated in quite a few problems. World-renowned specialists within the box talk about epidemiologic, anatomic, and physiologic facets, rfile the findings received with more recent imaging concepts, akin to spectral area optical coherence tomography, describe the remedies, and document at the result of preclinical and medical trials, together with a few formerly unpublished findings. This booklet will turn out worthy for ophthalmologists as we improve towards a destiny during which remedies of illnesses similar to age-related macular degeneration and diabetic retinopathy will most likely require adjunctive treatment to take on VMA/VMT concurrently.
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Extra resources for Diseases of the Vitreo-Macular Interface
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4). It has been hypothesized that these visible vitreous fibers form when HA molecules no longer separate the microscopic collagen fibrils, allowing the aggregation of collagen fibrils into bundles from which HA molecules are excluded (Ueno et al. 1987; Wolf and Gardiner 1965; Sebag 1987a). 4 Pathophysiology of the Aging Vitreous Fig. 1 Vitreous Cortex The posterior vitreous cortex (Fig. 5) is 100– 110 μm thick and consists of densely packed collagen fibrils in a lamellar organization rendering the appearance of sheets on immunohistochemistry (Fig.
Invest Ophthalmol Vis Sci 29:203 Gupta P, Sadun AA, Sebag J (2008) Multifocal retinal contraction in macular pucker analyzed by combined optical coherence tomography/scanning laser ophthalmoscopy. Retina 28:447–452 Gupta P, Yee KMP, Garcia P, Rosen RB, Parikh J, Hageman GS, Sadun AA, Sebag J (2011) Vitreoschisis in macular diseases. Br J Ophthalmol 95(3):376–380 Hamming NA, Apple DJ, Geiser DK, Vygantas CM (1977) Ultrastructure of hyaloid vasculature in primates. Invest Ophthalmol Vis Sci 16:408 Hiryama K, Hata Y, Noda Y et al (2004) The involvement of the rho-kinase pathway and its regulation in cytokine-induced collagen gel contraction by hyalocytes.