Diseases of the Liver and Biliary System in Children, Third

"An first-class up to date complete and sensible textual content e-book facing all facets of paediatric hepatobiliary sickness. it is going to be precious to either generalists and experts because it is clinically targeted with a problem-solving strategy and may be beneficial for daily in addition to extra esoteric medical difficulties. i discovered it precious in my basic paediatric perform and my trainees have additionally came upon it worthy. it's very functional with a diagnostic technique and many tables and medical pathways to stick with whilst faced with daily scientific difficulties. i've got road-tested it in genuine lifestyles with solid effect." - Judging Panel, 2004 BMA clinical booklet Competition

Diseases of the Liver and Biliary method in little ones, 3rd Edition offers a pragmatic method of the analysis and administration of paediatric liver illnesses, highlighting the significance of multidisciplinary group operating and holistic administration of the kid and relations. This totally revised version has additionally been up to date to hide fresh advances in paediatric hepatology. It comprises new chapters describing the consequences of liver disorder in being pregnant on mom and baby via to formative years. With expanding numbers of children surviving into grownup lifestyles this variation addresses the significance of coping with adolescent transition effectively.

Trainees, training paediatric gastroenterologists and hepatologists will welcome the sensible strategy defined during this textual content, whereas different healthcare execs fascinated about the administration of liver disorder in little ones will locate it an available and complete reference.

Chapter 1 constitution functionality and service of the Liver (pages 1–17): Ulrich Baumann, Alastair J.W. Millar and Rachel M. Brown
Chapter 2 The method of the kid with Liver illness: Differential prognosis and invaluable Investigations (pages 19–34): Deirdre A. Kelly
Chapter three the results of Liver ailment on mom and baby (pages 35–53): Jane Hartley and Elwyn Elias
Chapter four The Jaundiced child (pages 55–105): Eve A. Roberts
Chapter five The Acutely in poor health child (pages 106–125): Patrick J. McKiernan
Chapter 6 Infective problems of the Liver (pages 127–168): Suzanne Davison and Elizabeth H. Boxall
Chapter 7 Acute Liver Failure (pages 169–188): Peter F. Whitington, Estella M. Alonso and Robert H. Squires
Chapter eight Autoimmune Liver affliction (pages 189–206): Giorgina Mieli?Vergani and Diego Vergani
Chapter nine Drug?Induced Liver ailment (pages 207–230): Karen F. Murray
Chapter 10 Congenital and Structural Abnormalities of the Liver (pages 231–252): Jaime Liou Wolfe and Kathleen B. Schwarz
Chapter eleven Nonalcoholic Steatosis (pages 253–269): Eve A. Roberts
Chapter 12 Hepatobiliary disorder in Cystic Fibrosis (pages 270–288): Carla Colombo
Chapter thirteen Metabolic Liver disorder within the toddler and Older baby (pages 289–327): Anupam Chakrapani and Anne Green
Chapter 14 issues of Copper Metabolism (pages 328–347): Stuart Tanner
Chapter 15 issues and administration of persistent Liver sickness (pages 349–377): Ross Shepherd
Chapter sixteen The Liver in Systemic affliction (pages 379–403): Susan V. Beath
Chapter 17 pores and skin problems in Liver ailment (pages 404–419): Indra D.M. van Mourik and Michelle Thomson
Chapter 18 Dental Care of youngsters with Liver illness (pages 420–429): Marie?Therese Hosey and Victoria Clark
Chapter 19 Surgical problems of the Liver and Bile Ducts and Portal high blood pressure (pages 431–474): Alastair J.W. Millar
Chapter 20 fundamental Hepatic Tumors (pages 475–500): Bruce Morland and Jean de Ville de Goyet
Chapter 21 Liver Transplantation (pages 501–530): Deirdre A. Kelly and David Mayer
Chapter 22 Small?Bowel Transplantation in youngsters (pages 531–550): Jorge Reyes
Chapter 23 Liver illness within the constructing global (pages 551–576): Seng?Hock Quak, Anupam Sibal and Mei?Hwei Chang
Chapter 24 The position of the Multidisciplinary crew (pages 577–598): Graham Gordon, Julie Reed, Jacqueline Blyth and Carolyn J. Patchell
Chapter 25 formative years and Transition to grownup Care (pages 599–613): Janet E. McDonagh and Deirdre A. Kelly

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Additional resources for Diseases of the Liver and Biliary System in Children, Third Edition

Sample text

The main causes are infection (seronegative hepatitis), autoimmune hepatitis, drug toxicity (acetaminophen) and metabolic disease (see Chapter 7). 5). , methotrexate The clinical presentation varies from acute hepatitis to the insidious development of hepatosplenomegaly, cirrhosis, and portal hypertension with lethargy and malnutrition. Common symptoms include: • Intermittent fatigue, anorexia, and weight loss • Abdominal discomfort • Variable or fluctuating jaundice with pruritus and pale stools • Hematemesis or melena from variceal bleeding.

It is of most value in the diagnosis of Crohn’s disease, obscure or occult gastrointestinal bleeding, polyposis syndromes, and protein-losing enteropathy due to lymphangiectasia. 20 Neurophysiology Electroencephalography is mostly used in the assessment of hepatic encephalopathy. It will identify abnormal rhythms secondary to encephalopathy due to either acute or chronic liver failure or drug toxicity, such as post-transplant immunosuppression. It may also be of value for assessing brain death, as a flat electroencephalogram in the absence of sedation is an indication for withdrawal of therapy.

Correct information about coagulation parameters is vital. Prothrombin time should be within 3 s of control values; the platelet count should be > 80 × 109/L. The patient’s blood group should be known, and it is prudent to cross-match a unit of blood prior to the procedure. Biopsy specimens should be obtained for routine histopathology, microbiology, electron microscopy, immunohistochemistry, and copper (if appropriate), and snap-frozen in liquid nitrogen for enzymatic or metabolic investigations.

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