Dermatologic Clinics (Infectious Diseases, Volume 21, Number by Ted Rosen

By Ted Rosen

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If exposure to a susceptible individual occurs, notification of the patient with close observation by their treating physician is necessary. If infection results, the use of highdose intravenous immunoglobulin (IVIG) might be indicated, which results in fast and effective reversal of the anemia [29]. IVIG has been used to treat HPV B19-induced anemia in patients with immunodeficiency [30], transplant recipients [31,32], and AIDS [33]. Because the absolute risk of fetal death is low, maternal infection is not grounds for pregnancy termination.

Family member hospitalization, visitation to a hospital emergency room within the previous 6 months, inpatient or outpatient surgery, indwelling catheters, endotracheal tubes, and prolonged or recurrent antibiotic exposure are other known risk factors in the pediatric population [60 – 62]. Furthermore, healthcare worker or nursing home resident contact— and even child day care attendance—has been associated with MRSA transmission resulting in clinical infection [63,64].

Griseofulvin would not be expected to be effective against onychomycosis caused by Candida species or nondermatophyte molds [60]. Compared to dermatophytes, non-dermatophytes might require treatment Table 6 Treatment of Candida onychomycosis Reference Study type No. of patients (evaluable) Candida spp Segal et al, 1996 [8] Open 28 (20) Lestringant GG et al, 1996 [77] Open 32 (32) Rashid et al, [80] Open, noncomparative 13 (13) Gupta et al, 2000 [78] Open, multicenter 44 (32) Lebwohl et al, 2001 [73] DB, randomized, placebo-controlled, multicenter DB, randomized, placebo-controlled, multicenter 12 (12) 11 (11) TER 250 mg/day for 24 weeks.

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