Comprehensive Medicinal Chemistry II, Volume 7 : Therapeutic by David J Triggle, John B Taylor

By David J Triggle, John B Taylor

The 1st variation of finished Medicinal Chemistry was once released in 1990 and was once rather well got. finished Medicinal Chemistry II is far greater than an easy updating of the contents of the 1st version. thoroughly revised and multiplied, this new version has been refocused to mirror the numerous advancements and adjustments during the last decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and extra. The content material includes the main up to date, authoritative and entire reference textual content on modern medicinal chemistry and drug study, masking significant healing sessions and ambitions, study method and company, high-throughput applied sciences, computer-assisted layout, ADME and chosen case histories. it's this assurance of the tactic, applied sciences, ideas and functions of medicinal chemistry in one paintings that would make finished Medicinal Chemistry II a special paintings of reference and a unmarried element of access to the literature for pharmaceutical and biotechnology scientists of all disciplines and for lots of executives as well.Also to be had on-line through ScienceDirect (2006) - that includes vast looking, looking out, and inner cross-referencing among articles within the paintings, plus dynamic linking to magazine articles and summary databases, making navigation versatile and simple. for additional info, pricing strategies and availability stopover at www.info.sciencedirect.com. * Comprehensively stories - the innovations, applied sciences, ideas and purposes of recent medicinal chemistry * offers an international and present standpoint of contemporary drug discovery approach and discusses the key healing periods and objectives* incorporates a particular choice of case reviews and private assays reviewing the invention and improvement of key medications

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Extra resources for Comprehensive Medicinal Chemistry II, Volume 7 : Therapeutic Areas II: Cancer, Infectious Diseases, Inflammation & Immunology and Dermatology

Sample text

Apte, S. ; Killion, J. ; Fidler, I. J. M. Clin. Cancer Res. 2004, 10, 897–908. ; Betsholtz, C. Circulation 2002, 105, 12–117. ; Hanahan, D. J. Clin. Invest. 2003, 111, 1287–1295. ; Heldin, C. ; Funa, K. Proc. Natl. Acad. Sci. USA 1988, 85, 7748–7752. ; Kim, S. ; Shepherd, D. ; Killion, J. ; Fidler, I. J. J. Natl. Cancer Inst. 2003, 95, 458–470. ; Heldin, C. ; Westermark, B. Proc. Natl. Acad. Sci. USA 1993, 90, 393–397. ; Reed, R. ; Heldin, C. ; Rubin, K. Cancer Res. 2001, 61, 2929–2934. ; Heldin, C.

Biochim. Biophys. Acta 1994, 1198, 165–184. ; Worobec, A. ; Metcalfe, D. D. J. Allergy Clin. Immunol. 1997, 100, 435–440. Longley, B. ; Reguera, M. ; Ma, Y. Leukemia Res. 2001, 25, 571–576. Huizinga, J. ; Mikkelsen, H. ; Bernstein, A. Nature 1995, 373, 347–349. ; Takeda, M. et al. Science 1998, 279, 577–580. ; Roberts, P. ; Andersson, L. ; Druker, B. et al. N. Engl. J. Med. 2001, 344, 1052–1056. ; Sherr, C. ; Roussel, M. F. Proc. Natl. Acad. Sci. USA 1998, 95, 1091–1096. Sebolt-Leopold, J. ; Herrera, R.

Apte, S. ; Killion, J. ; Fidler, I. J. M. Clin. Cancer Res. 2004, 10, 897–908. ; Betsholtz, C. Circulation 2002, 105, 12–117. ; Hanahan, D. J. Clin. Invest. 2003, 111, 1287–1295. ; Heldin, C. ; Funa, K. Proc. Natl. Acad. Sci. USA 1988, 85, 7748–7752. ; Kim, S. ; Shepherd, D. ; Killion, J. ; Fidler, I. J. J. Natl. Cancer Inst. 2003, 95, 458–470. ; Heldin, C. ; Westermark, B. Proc. Natl. Acad. Sci. USA 1993, 90, 393–397. ; Reed, R. ; Heldin, C. ; Rubin, K. Cancer Res. 2001, 61, 2929–2934. ; Heldin, C.

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