By Kenneth B. Calder, Bruce R. Smoller (auth.), Bruce R. Smoller, Franco Rongioletti (eds.)
Through a special presentation of medical pictures and accompanying histologic photomicrographs, medical and Pathological elements of epidermis illnesses in Endocrine, Metabolic, dietary and Deposition illness presents the working towards surgical pathologist, dermatologist, endocrinologist, inner medication health care professional and dermatopathologist with a unmarried quantity resource that stories the medical and pathologic positive aspects of metabolic and endocrine issues that exhibit cutaneous manifestations. colour photos are awarded for every by way of a chain of phoromicrographs depicting each one entity microscopically. The textual content contains scientific gains, Pathology, Etiopathogenesis, Differential prognosis and treatment for all entities, defined in a transparent, concise type. In-depth discussions of the scientific findings, in addition to the histologic positive factors of those illnesses are integrated. also, laboratory facts used to make and aid the diagnoses is mentioned for every entity. the 1st part covers metabolic problems that experience cutaneous manifestations. ailments geared up through the endocrine organ basically chargeable for the systemic are lined. for every entity, an atlas of medical manifestations is gifted that would function a “bed-side” scientific reference, by way of a chain of photomicrographs depicting the histologic alterations. This designated layout of presentation is through the quantity within the moment via fourth sections addressing Metabolic ailments, dietary issues that impact the outside and eventually Cutaneous Deposition problems. scientific and Pathological points of dermis illnesses in Endocrine, Metabolic, dietary and Deposition affliction is a distinct reference for the working towards dermatopathologist, normal pathologist reviewing dermis biopsies, common dermatologists, internists and endocrinologists.
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Additional info for Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease
In hypothyroidism, the skin is usually thick, yellowish (due to carotenemia), cold, and dry with livedo on the extremities. 13) are often reported . The thyroid hormone is well known to 32 A. Rebora and F. 12 Generalized myxedema. 14 Alopecia in hypothyroidism Secondary myxedema depends on the failure of the pituitary gland to stimulate thyroid. The symptoms and signs are the same as in primary myxedema, but goiter, obesity, and hypothermia are absent. The voice is less coarse, and there is amenorrhea and absence of lactation, while in primary myxedema menses and lactation are normal.
14). They appear in crops on the buttocks, extensor surfaces of the extremities, and flexural creases. Pruritus and Koebner reaction may be present. Histologically, foamy macrophages Acquired perforating dermatosis is a rare disorder seen in adult patients, especially those presenting with type 2 and type 1 diabetes mellitus (50%) and with chronic renal failure (73%) . 9%) had chronic renal failure because of diabetic nephropathy. 16b). Koebner phenomenon is seen in 32% of patients. The histological features are not uniform, and may resemble any of the four classic perforating disorders: elastosis perforans serpiginosa, reactive perforating collagenosis, perforating folliculitis, or Kyrle’s disease.
The pathogenesis is most likely related to high levels of circulating insulin, which binds to insulin-like growth factor receptors to stimulate the growth of keratinocytes and dermal fibroblasts. 9 Miscellanea “Yellow nails and skin” is a benign condition associated with diabetes whose significance is unknown. The tinctoral change may be due to either high levels of carotene or non-enzymatic glycosylation of dermal collagen. 22). The association between diabetes and lichen planus is controversial.