Chemical Genomics: Reviews and Protocols by Paul R. Caron (auth.), Edward D. Zanders PhD (eds.)

By Paul R. Caron (auth.), Edward D. Zanders PhD (eds.)

Chemical genomics is an exhilarating new box that provides to remodel organic chemistry right into a high-throughput industrialized strategy, a lot within the similar means that genomics has reworked molecular biology. In Chemical Genomics: experiences and Protocols, cutting edge researchers introduce the uninitiated into some of the "flavors" of chemical genomics and describe a chain of with no trouble reproducible recommendations for functions in natural chemistry, protein chemistry, and desktop technology, with emphasis at the high-throughput ways which are the essence of chemical genomics. The recommendations diversity from the vintage layout of small molecules as affinity ligands for particular protein households, to in silico docking for computational ways, to protein-small molecule interactions, to generating hugely diversified collections of proteins, carbohydrates, and small molecules to be used in arrays containing huge numbers of those molecules. There also are tools for the creation of proteins and carbohydrates utilizing assorted expression platforms, for interpreting proteins utilizing mass spectrometry, and for arraying proteins and carbohydrates on strong helps. The protocols stick with the profitable tools in Molecular Biology™ sequence layout, every one providing step by step laboratory directions, an creation outlining the foundations at the back of the strategy, lists of the required apparatus and reagents, and pointers on troubleshooting and averting recognized pitfalls.
Authoritative and well timed, Chemical Genomics: studies and Protocols deals researchers an available advent by means of pioneers to the major parts and strategies of chemical genomics, in addition to its use within the discovery and overview of novel drug targets.

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Science 298, 1912– 1934. 24. , and Singh, J. (2004) Structural Interaction Fingerprint (SIFt): a novel method for analyzing three-dimensional protein-ligand binding interactions. J. Med. Chem. 47, 337–344. 25. Weber, L. Fractal theory applied to structure-activity relationships. Euro-QSAR 2004, Istanbul, Turkey, September 5–10, 2005. 26. Verdine, L. G. (1996) The combinatorial chemistry of nature. Nature 384, 11–13. Chemistry for Chemical Genomics 23 27. -L. and Schneider, G. (2001) Scaffold architecture and pharmacophoric properties of trade drugs and natural products.

2004) Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305, 399–4001. 9. Koonin, E. V. PDOC0017, last revised July 1999. 10. , and Singh, J. (2004). Structural interaction fingerprint (SIFt): a novel method for analyzing three-dimensional protein-ligand binding interactions. J. Med. Chem. 47, 337–344. 11. , and Cygler, M. (2003) Coverage of protein sequence space by current structural genomics. J. Struct. Func. Genomics 4, 47–55. 12. Todorov, N. P. and Dean, P. M. (1997) An evaluation of a method for controlling molecular scaffold diversity in de novo ligand design.

Buenemann, C. , Todorov, N. , Manallack, D. , and Dean, P. M. (2004) Scaffold hopping in de novo drug design—ligand generation in the absence of receptor information. J. Med. Chem. 47, 493–496. 40 Dean Biomimetic Ligands for Affinity Chromatography II PROTOCOLS 41 42 Roque, Gupta, and Lowe Biomimetic Ligands for Affinity Chromatography 43 4 Design, Synthesis, and Screening of Biomimetic Ligands for Affinity Chromatography Ana Cecília A. Roque, Geeta Gupta, and Christopher R. Lowe Summary Affinity chromatography is ideally suited to the purification of pharmaceutical proteins due to its unique bio-specificity characteristics.

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