Biological Toxins and Bioterrorism: Biological Toxins and by P. Gopalakrishnakone (eds.)

By P. Gopalakrishnakone (eds.)

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Nat Rev Drug Discov. 2011;10(4):307–17. Stura EA, Le Roux L, Guitot K, Garcia S, Bregant S, Beau F, Vera L, Collet G, Ptchelkine D, Bakirci H, Dive V. Structural framework for covalent inhibition of Clostridium botulinum neurotoxin A by targeting Cys165. J Biol Chem. 2012;287(40):33607–14. Thompson AA, Jiao GS, Kim S, Thai A, Cregar-Hernandez L, Margosiak SA, Johnson AT, Han GW, O’Malley S, Stevens RC. Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the Clostridium botulinum serotype A neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility.

2013). Category B is a broad group that includes bacteria, viruses, toxins, and protozoa. Agents in this group are potentially attractive as biothreat agents but have a lesser ability to cause mass casualty events. They are not easily disseminated in large-scale attacks, but they still can cause major disruptions and strain public health and primary care resources (Pappas et al. 2006). Ricin, SEB, and epsilon toxin fall into this category. Though not listed as such, abrin would likely fall into this category because it is structurally and functionally similar to ricin, has a similar toxicity, and can be extracted from seeds (Abrus precatorius) that are readily available.

Some of these labs may also measure human exposure to toxic chemicals. Member labs consist of selected military labs operated by the Department of Defense, including USAMRIID, food-testing labs within FDA and USDA, environmental labs capable of testing water and environmental samples, veterinary labs run by USDA, and select international labs in Canada, the United Kingdom, Australia, Mexico, and South Korea. Laboratories at the highest level are those operated by CDC, USDA, and DoD. Figure 2 below diagrams the LRN hierarchy and primary responsibility at each level (Pien et al.

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