Biocatalysis for the Pharmaceutical Industry: Discovery, by Junhua (Alex) Tao, Guo-Qiang Lin, Andreas Liese

By Junhua (Alex) Tao, Guo-Qiang Lin, Andreas Liese

Biocatalysis is speedily evolving right into a key know-how for the invention and construction of chemical compounds, specifically within the pharmaceutical undefined, the place excessive yielding chemo-, regio-, and enantioselective reactions are severe. Taking the newest breakthroughs in genomics and proteomics under consideration, Biocatalysis for the Pharmaceutical Industry concisely but comprehensively discusses the trendy program of biocatalysis to drug discovery, improvement, and production. Written by means of a group of top specialists, the ebook bargains deep perception into this leading edge box.

  • Covers a variety of issues in a scientific demeanour with an emphasis on business functions
  • Provides an intensive creation to the most recent biocatalysts, sleek expression hosts, state of the art directed evolution, excessive throughput screening, and bioprocess engineering
  • Addresses frontier matters akin to rising enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and self sustaining enzymes for the synthesis and improvement of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and common product analogs
  • Highlights the effect of biocatalysis on eco-friendly chemistry
  • Contains various images to demonstrate strategies and methods

Biocatalysis for the Pharmaceutical Industry is an important source for scientists, engineers, and R&D coverage makers within the wonderful chemical, pharmaceutical, and biotech industries. it's also a useful device for educational researchers and complicated scholars of natural and fabrics synthesis, chemical biology, and medicinal chemistry.Content:
Chapter 1 Enzymes and Their man made functions: an outline (pages 1–19): Junhua (Alex) Tao and Jian?He Xu
Chapter 2 Expression Hosts for Enzyme Discovery and construction (pages 21–44): Aleksandra Andryushkova and Anton Glieder
Chapter three Directed Enzyme Evolution and High?Throughput Screening (pages 45–64): Michael J. McLachlan, Ryan P. Sullivan and Huimin Zhao
Chapter four purposes of response Engineering to business Biotransformations (pages 65–88): Lutz Hilterhaus and Andreas Liese
Chapter five Chiral Synthesis of Pharmaceutical Intermediates utilizing Oxynitrilases (pages 89–109): Wen?Ya Lu and Guo?Qiang Lin
Chapter 6 increasing the Scope of Aldolases as instruments for natural Synthesis (pages 111–119): William A. Greenberg
Chapter 7 artificial functions of Ketoreductases and Alcohol Oxidases (pages 121–151): Dunming Zhu and Ling Hua
Chapter eight purposes of Nitrile Hydratases and Nitrilases (pages 153–181): Grace DeSantis and Robert DiCosimo
Chapter nine Biosynthesis of Drug Metabolites (pages 183–211): Wenying Li, David Rozzell, Spiros Kambourakis and Martin Mayhew
Chapter 10 program of Whole?Cell Biotransformation within the Pharmaceutical (pages 213–227): kinfolk Sing Lam
Chapter eleven Combinatorial Biosynthesis of Pharmaceutical usual items (pages 229–245): Wen Liu and Yi Yu
Chapter 12 Metabolic Engineering for the improvement and production of prescribed drugs (pages 247–271): Dongping Lu, Philip G. Williams and Guangyi Wang
Chapter thirteen Multimodular Synthases and helping Enzymes for Chemical construction (pages 273–303): Michael Burkart and Junhua (Alex) Tao
Chapter 14 eco-friendly Chemistry with Biocatalysis for construction of prescribed drugs (pages 305–321): Oliver might

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J. et al. (2007) Comparison of different strategies to reduce acetate formation in Escherichia coli. Biotechnology Progress, 23 (5), 1053–1063. , Nedal, A. et al. (2007) The presence of N-terminal secretion signal sequences leads to strong stimulation of the total expression levels of three tested medically important proteins during high-cell-density cultivations of Pichia pastoris. Applied and Environmental Microbiology, 73 (3), 906–912. , Ikezawa, H. J. (1976) Factors affecting the acyl selectivities of acyltransferases in Escherichia coli.

Periplasmatic expression has even more advantages for protein expression [33]: it also simplifies downstream processing, N-terminal processing and correct folding, and can reduce proteolysis. Also, combinations like chaperone coexpression and export to the periplasm using, for example, the twin-arginine translocation (TAT) secretion system, which is able to secrete folded proteins, can be very successful [34]. Nevertheless, incomplete translocation across the inner membrane and existence still of proteolytic degradation can lower the yield significantly.

1997) Isolation of Bacillus megaterium mutants that produce high levels of heterologous protein, and their use to construct a highly mosquitocidal strain. Current Microbiology, 35 (2), 71–76. , Asami, O. et al.

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