By Fariba Behbod, Gailen D. Marshall Jr. (auth.), Phillip L. Lieberman MD, Michael S. Blaiss MD (eds.)
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Chemokine families, receptors, and their positions. A, Chemokine families are determined by the position of the initial cysteine residues. CXC chemokines have their first two cysteine residues separated by one amino acid, whereas CC chemokines have no break between their first two cysteine residues . B, There are four families of chemokines of potential importance in allergy and asthma 151. Each chemokine can bind to different receptors expressed on particular cell types. For example, CXC chemokines are chemotactic for neutrophils and lymphocytes, whereas CC chemokines attract monocytes, eosinophils, basophils, and lymphocytes.
Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. Am} Respir Cell M()I Bioi 1997, 17: 683-690. 4. Luster AD: Chemokines: chemotactic cytokines that mediate inflammation. N r:nglJ Med 19n, 33X:436-445. 5. Busse WW, Lemanske RF: Advances ill immullology: asthma. N Engl J Med 2001, 344: 350-360. 6. Gagner Y, Oppenheim JJ: Are chemokines essential or secondary participants in allergic responses? AIlII Allergy Asthma Inmlun()1 2000, 84:569-578.
In addition, epithelial desquamation, goblet cell hyperplasia, and a thickened sub-basement membrane are present. (From Busse and Lemanske [11; with permission). 45 The Eosinophil Morphology of Eo inophils and Eosin phil Products Figure 6-4. Figure G-3. Electron photomicrograph of an eosinophil. Eosinophils contain many granules. Particularly distinctive are the specific or secondary granules. This electron photomicrograph (magnification X 10,(00) shows that these granules contain an electrondense crystalloid core (C) and a less-dense matrix (M).