By American Chemical Society
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Extra resources for Agricultural Control Chemicals - Symposia on Economic Poisons - 115th Ntl. Mtg. San Francisco, March 28 to April 1, 1949, 116th Ntl. Mtg. Atlantic City, September 18 to 23, 1949
4 4 149 127 134 62 1 1 7 3 7 7 1 4 2 3 7 7 4 2 5 6/10 2 3 1 3 6 2 2 8 0 1 2 5 119 385 121 8/10 5/8 4/6 9/9 5/8*' Table IV. M. M. Control 50 100 No. of Rats Start Finish 10 10 8 6 8 5 Total Food and Parathion Consumed, G . Control 50 100 132,955 103,284 % Mortality o f 40 20 38 Average Weight, G . /rat/day, Total, g. g. /rat/day, Total, g. g. , and the corresponding control group, were sacrificed b y exsanguination through a cardiac puncture following light ether anesthesia. A n autopsy was performed on each rat immediately following death.
M. group. This indicates that the majority of the animals were lost relatively late i n the 2-year period. I t is probable that the difference i n either mortality or survival is not significant. W i t h the upper tolerable limits thus established, three additional groups of 20 male rats each were started. m. Shortly after the second series of experiments was started a minor epidemic of respiratory disease was responsible for several deaths, particularly i n the control group, and these animals were eliminated from further consideration, because experiments of this type are designed to cover infantile rats i n the 60- to 70-gram weight range and i t was i m possible to replace them.
But continually manifested evidence of toxicity and presented an unthrifty appearance. I t is evident, therefore, that chronic toxicity follows a sex pattern comparable to the acute toxicity. Table III. Summary of Body Weight and Food Consumption after Various Intervals of Feeding (Parathion was added to diets in form of carefully prepared dust. m. are as parathion. All values are average for number of survivors. Omissions in female series cover periods of parturition and lactation) Males Males Females Control 10 P .